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Disease Profile
Sixth nerve palsy
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Cranial mononeuropathy VI; Abducens nerve palsy; Sixth cranial nerve palsy;
Summary
Sixth nerve palsy is a nerve disorder that occurs when the sixth cranial nerve is damaged. The disorder prevents some of the muscles that control eye movement from working properly. Affected people cannot turn the eye outwards toward the ear. Other signs and symptoms may include double vision, headaches, and pain around the eye. Sixth nerve palsy may be caused by many things, including stroke, brain aneurysm, diabetic neuropathy, trauma, infections, inflammation,
Cause
- Stroke
- Trauma
- Viral illness
- Brain
tumors - Inflammation
- Infections (such as
meningitis ) - Migraine headaches
- Elevated pressure inside the brain
- Gradenigo's
syndrome (which also causes ear discharge and eye pain) - Multiple sclerosis
- Pregnancy
- Brain aneurysms
- Small-vessel disease, particularly in diabetics (diabetic neuropathy)
The condition can be present at birth, but the most common cause in children is trauma. In some people, there is no clear cause.[1][3]
Diagnosis
Treatment
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The American Association for Pediatric Ophthalmology and Strabismus (AAPOS) provides information about sixth nerve palsy. Click on the link to view information related to this topic.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Merck Manual for health care professionals provides information on Sixth nerve palsy.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Sixth nerve palsy. Click on the link to view a sample search on this topic.
References
- Sixth Nerve Palsy. AAPOS. August 2014; https://www.aapos.org/terms/conditions/98.
- Cranial Mononeuropathy VI. MedlinePlus. May 21, 2012; https://www.nlm.nih.gov/medlineplus/ency/article/000690.htm. Accessed 3/24/2014.
- Dugdale DC, Hoch DB. Cranial mononeuropathy VI. MedlinePlus. May 2014; https://www.nlm.nih.gov/medlineplus/ency/article/000690.htm.
- Michael P Ehrenhaus, MD. Abducens Nerve Palsy. Medscape Reference. February 2014; https://emedicine.medscape.com/article/1198383-overview.
- Andrew G Lee, MD; Paul W Brazis, MD. Sixth cranial nerve (abducens nerve) palsy in children. UpToDate. May 2015; Accessed 10/15/2015.
- Siddharth Agrawal, Vinita Singh, and Saurabh Agrawal. Congenital sixth nerve palsy or Type I Duane syndrome?. Oman J Ophthalmol. May-August, 2011; 4(2):92-94. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160079/.
- Carr MM, Ross DA, Zuker RM. Cranial nerve defects in congenital facial palsy. J Otolaryngol. April, 1997; 26(2):80-87. https://www.ncbi.nlm.nih.gov/pubmed/9106081.
- Sixth Nerve Palsy. American Association for Pediatric Ophthalmology and Strabismus. 2011; https://www.aapos.org/terms/conditions/98. Accessed 8/19/2011.
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