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Disease Profile

Drug induced dyskinesia

Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.

Unknown

Age of onset

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ICD-10

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Inheritance

Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease

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Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype

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X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.

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X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder

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Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.

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Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.

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Not applicable

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Other names (AKA)

Dyskinesia, drug induced

Summary

Drug induced dyskinesia is an involuntary movement disorder. Signs and symptoms include repetitive and irregular motions of the mouth, face, limbs and/or trunk.[1] Treatment with antipsychotic drugs and levodopa (commonly used to treat Parkinson disease) are well recognized causes of drug-induced dyskinesia.[1][2][3] Dyskinesia develops in around 40% of people with Parkinson's disease who have been on levodopa treatment for four to six years.[3] Tardive dyskinesia is a severe form of drug-induced dyskinesia due to antipsychotic treatments. Tardive dyskinesia develops in 5% of people per year of treatment.[2]

Cause

The following medications have caused drug-induced dyskinesia in some individuals:[1][4]

  • Levodopa
  • Chlorpromazine
  • Fluphenazine
  • Haloperidol
  • Trifluoperazine
  • Flunarizine (Sibelium)
  • Metoclopramide
  • Prochlorperazine

Learn more

These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

In-Depth Information

  • PubMed is a searchable database of medical literature and lists journal articles that discuss Drug induced dyskinesia. Click on the link to view a sample search on this topic.

References

  1. Loonen AJ, Ivanova SA. New insights into the mechanism of drug-induced dyskinesia. CNS Spectr. 2013 Feb;18(1):15-20; https://www.ncbi.nlm.nih.gov/pubmed/23593652. Accessed 10/22/2013.
  2. Akbostanci MC, Atbasoglu EC, Balaban H. Tardive dyskinesia, mild drug-induced dyskinesia, and drug-induced parkinsonism: risk factors and topographic distribution. Acta Neurol Belg. 1999 Sep;99(3):176-81; https://www.ncbi.nlm.nih.gov/pubmed/10544725. Accessed 10/22/2013.
  3. Damier P. Drug-induced dyskinesias. Curr Opin Neurol. 2009 Aug;22(4):394-9; https://www.ncbi.nlm.nih.gov/pubmed/19491677. Accessed 10/22/2013.
  4. Tardive dyskinesia. MedlinePlus. May 21, 2012; https://www.nlm.nih.gov/medlineplus/ency/article/000685.htm. Accessed 10/22/2013.

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