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Disease Profile

Collagenous gastritis

Prevalence
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.

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Age of onset

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ICD-10

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Inheritance

Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.

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Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.

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X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.

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X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.

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Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.

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Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.

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Not applicable

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Categories

Digestive Diseases

Summary

Collagenous gastritis (CG) is a rare condition that primarily affects the digestive system. People with CG have increased buildup of collagen in the subepithelial layer of the stomach.[1][2] This condition typically affects children and young adults up to 22 years, or older adults over 35 years of age. Signs and symptoms appear to vary depending on the age group. Initial symptoms in children and young adults often include anemia and abdominal pain, whereas older adults often have chronic watery diarrhea associated with collagenous colitis, celiac disease or both.[1][3] Adult collagenous gastritis is also associated with autoimmune diseases such as Sjögren syndrome, lymphocytic gastritis, lymphocytic colitis, and ulcerative colitis.[3] Other signs and symptoms of CG may include nausea and vomiting, weight loss, abdominal distention, and gastrointestinal bleeding.[3] The cause of the condition is unclear.[1] Because of the small number of cases, no standard therapy for CG has been established based on randomized, controlled clinical trials.[3]

Treatment

Because collagenous gastritis is very rare and its cause is unknown, there is currently no established standard therapy for the condition. Various therapies have been attempted with limited success. These have included anti-secretary agents, steroids, iron supplementation, and hypoallergenic diets. Several other therapies have also been tested. A few affected people have shown improvement of symptoms, but no randomized, controlled trials have been performed. More studies are needed to establish a standard treatment strategy.[3]

Organizations

Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.

Organizations Supporting this Disease

    Organizations Providing General Support

      Learn more

      These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.

      In-Depth Information

      • PubMed is a searchable database of medical literature and lists journal articles that discuss Collagenous gastritis. Click on the link to view a sample search on this topic.

        References

        1. Brain O, Rajaguru C, Warren B, Booth J, Travis S. Collagenous gastritis: reports and systematic review. Eur J Gastroenterol Hepatol. December 2009; 21(12):1419-1424. https://www.ncbi.nlm.nih.gov/pubmed/19730387.
        2. Kori M, Cohen S, Levine A, Givony S, Sokolovskaia-Ziv N, Melzer E, Granot E. Collagenous gastritis: a rare cause of abdominal pain and iron-deficiency anemia. J Pediatr Gastroenterol Nutr. November 2007; 45(5):603-606. https://www.ncbi.nlm.nih.gov/pubmed/18030241.
        3. Kamimura K, Kobayashi M, Sato Y, Aoyagi Y, Terai S. Collagenous gastritis: Review. World J Gastrointest Endosc. March 16, 2015; 7(3):265-273. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360446/.
        4. Hijaz NM, Septer SS, Degaetano J, Attard TM. Clinical outcome of pediatric collagenous gastritis: case series and review of literature. World J Gastroenterol. March 7, 2013; 19(9):1478-1484. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602509/.
        5. Ma C, et. al. A Comparative Clinicopathologic Study of Collagenous Gastritis in Children and Adults: The Same Disorder With Associated Immune-mediated Diseases. Am J Surg Pathol. 2015 Jun; 39(6):802-12. https://www.ncbi.nlm.nih.gov/pubmed/?term=25871617.
        6. Rohan Mandaliya, Anthony J. DiMarino, Sheeja Abraham, Ashlie Burkart, Sidney Cohen. Collagenous Gastritis a Rare Disorder in Search of a Disease. Gastroenterology Research. 2013; 6(4):139-144. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074812/.

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