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5 Facts you should know about

Spinal muscular atrophy (SMA)



The term spinal muscular atrophy (SMA) refers to a group of genetic disorders all characterized by degeneration of anterior horn cells and resultant muscle atrophy and weakness


The severity of SMA is highly variable and the clinical features can be classified into 4 main phenotypes on the basis of age of onset and maximum motor function achieved


The clinical severity of SMA correlates inversely with SMN2 gene copy number and varies from extreme weakness and paraplegia of infancy to a mild proximal weakness of adulthood


The incidence of SMA in the United States is 1:10,000/11,000 live births


SMA affects individuals of all ethnic groups

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