Rare Gastroenterology News

5 Facts you should know about

Activated PI3K delta syndrome (APDS)

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1

APDS, a Primary Immunodeficiency, was only characterized in 2013,

although it shares many features of other immune disorders - which means APDS patients may have been previously misdiagnosed with other conditions

2

Signs and symptoms of APDS start in childhood, and patients are vulnerable to repeat infections and immune dysregulation

such as inflammatory auto immune disorders, enteropathies, lymphadenopathy, and even lymphoma

3

Patients with APDS may seek care from gastroenterologists because of chronic enteritis

4

Overproduction of B and T cells has been shown to appear

as nodules in the airway or digestive tract for 24%-36% of people with APDS

5

Genetic testing is the only way to definitively diagnose APDS and other primary immunodeficiencies